The Laboratory of Personality and Cognition across the Lifespan (LPCLifespan) at the Florida State University College of Medicine examines the interplay between personality and other psychological factors and cognitive function. We take an intergenerational lifespan approach to address the early environmental origins of personality and cognition, how personality and cognition co-develop across the lifespan, and the mechanisms through which personality contributes to risk of Alzheimer’s disease and related dementias. Other major lines of research include the role of purpose in life in healthier cognitive outcomes across the lifespan and the consequences of weight stigma for physical, cognitive, and emotional well-being. Our research is multidisciplinary and spans from genetics to cross-cultural studies.